[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"skill:01M6FSGBN1J8ZTDJSJEJSAFGSA":3,"skill-same:01M6FSGBN1J8ZTDJSJEJSAFGSA":53},{"skillNo":4,"name":5,"nameZh":6,"description":6,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":14,"categories":15,"keywords":21,"publishedAt":22,"linkOnly":23,"markdownContent":24,"markdownBody":24,"frontMatter":25,"refName":26,"commitSha":27,"skillDirectory":28,"forksCount":29,"repositoryHtmlUrl":30,"repositoryHomepageUrl":6,"ownerHtmlUrl":31,"ownerBlogUrl":6,"ownerDescription":6,"updatedAt":32,"install":33,"resources":46},"01M6FSGBN1J8ZTDJSJEJSAFGSA","refua",null,"kbarbel640-del\u002Fskills","kbarbel640-del","https:\u002F\u002Favatars.githubusercontent.com\u002Fu\u002F255315490?v=4","01M6CJPPQGCCESXMG3K7BBGQ5J","01M6CJPPX2PB2BCZERFVM2C2B3",1,"MIT","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fjbenjoseph\u002Frefua\u002FSKILL.md",[16],{"categoryNo":17,"categoryName":18,"taxonomyType":19,"taxonomyTypeDesc":20},"01JBSEEDCAT000000000000023","Skill与智能体开发","SCENARIO","使用场景",[5],"2026-11-10 10:12:30",false,"# Skill: Refua\n\n## Summary\nRefua is used in drug discovery to computationally fold and score biomolecular complexes (e.g., protein–ligand\u002Fprotein–protein) and optionally profile ADMET, helping prioritize which molecules to synthesize and test first in a drug discovery pipeline.\n\nThis skill runs and connects to the **refua-mcp** MCP server, which exposes Refua’s “unified Complex API” as MCP tools for:\n- **Boltz2** complex folding (+ optional affinity evaluation)\n- **BoltzGen** design workflows\n- Optional **ADMET** profiling (when installed)\n\nClawdbot supports MCP natively, so the only requirement is running this MCP server and calling its tools. ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n\n---\n\n## When to use\nUse this skill when you need to:\n- Fold a **protein–ligand**, **protein–protein**, or (fold-only) **DNA\u002FRNA** complex\n- Estimate **binding affinity** for a specified binder within a complex spec\n- Run **ADMET** predictions for one or more SMILES ligands (if enabled)\n- Execute GPU\u002FCPU-heavy Refua workflows via MCP tool calls\n\nDo NOT use this skill when:\n- The task is a simple deterministic calculation (prefer a non-ML tool)\n- The user expects you to invent sequences\u002FSMILES (request inputs instead)\n- The user requests unsafe wet-lab or clinical guidance\n\n---\n\n## Installation & assets (operator steps)\n\n### 1) Install Refua + refua-mcp\nInstall Refua (CPU or CUDA), then install the MCP server package: ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n\n- GPU support:\n  - `pip install refua[cuda]`\n- CPU-only:\n  - `pip install refua`\n- MCP server:\n  - `pip install refua-mcp`\n\n### 2) Optional: enable ADMET\nADMET tool support is optional and requires an extra: ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n- `pip install refua[admet]`\n\n### 3) Download model\u002Fassets\nBoltz2 and BoltzGen require model\u002Fmolecule assets. Refua can download them automatically: ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n- `python -c \"from refua import download_assets; download_assets()\"`\n\nDefault asset locations + overrides: ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n- **Boltz2** uses `~\u002F.boltz` by default  \n  - Override via tool option `boltz.cache_dir` if needed\n- **BoltzGen** uses a bundled HF artifact by default  \n  - Override via tool option `boltzgen.mol_dir` if needed\n\n---\n\n## Running the MCP server\nStart the server using the module entrypoint: ([github.com](https:\u002F\u002Fgithub.com\u002Fagentcures\u002Frefua-mcp))\n\n```bash\npython3 -m refua_mcp.server\n```",{},"main","e7e336ac628c3e3bd771aff1aaa469c93778f94a","skills\u002Fjbenjoseph\u002Frefua",0,"https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del","2026-08-23 22:39:37",{"source":7,"skillName":5,"commands":34,"prompt":44,"zipAvailable":45},[35,38,41],{"tool":36,"command":37},"npx","npx skills add kbarbel640-del\u002Fskills --skill refua",{"tool":39,"command":40},"bunx","bunx skills add kbarbel640-del\u002Fskills --skill refua",{"tool":42,"command":43},"pnpm","pnpm dlx skills add kbarbel640-del\u002Fskills --skill refua","安装技能，技能地址：https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fjbenjoseph\u002Frefua\u002FSKILL.md",true,[47],{"path":48,"resourceType":49,"resourceTypeDesc":50,"sizeBytes":51,"sourceHtmlUrl":52},"_meta.json","REFERENCE","参考文档",266,"https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fjbenjoseph\u002Frefua\u002F_meta.json",[54,85,110,131,137,157],{"skillNo":55,"name":56,"nameZh":6,"description":57,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":58,"categories":59,"keywords":65,"publishedAt":22},"01M6G8J55967D6281ACMKAKTEQ","crowd-prompting","A marketplace where AI agents improve prompts, system instructions, tool descriptions, and other text-based content with domain expertise from real-world operations — and earn tokens for valuable contributions.","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fzzadrian\u002Fcrowd-prompting\u002FSKILL.md",[60],{"categoryNo":61,"categoryName":62,"taxonomyType":63,"taxonomyTypeDesc":64},"01JBSEEDCAT000000000000036","内容创作者","PROFESSION","适用职业",[66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84],"crowd prompting","prompting","api","with","tokens","domain","world","prompts","operations","instructions","text","tool","system","improve","productivity","marketplace","https","content","ai agents",{"skillNo":86,"name":87,"nameZh":6,"description":88,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":89,"categories":90,"keywords":92,"publishedAt":22},"01M6G8J0PKPAYVET6BWE8W4C26","dilemm-ai","Compete in DilemmAI, the prisoner's dilemma AI arena at dilemm.ai. Use when an OpenClaw agent wants to create an account, design and submit strategy prompts for their bot, enter matchmaking, analyze historical matches and leaderboards, and iterate on bot strategy. Requires headless browser automation (no API available yet).","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fzyori\u002Fdilemm-ai\u002FSKILL.md",[91],{"categoryNo":17,"categoryName":18,"taxonomyType":19,"taxonomyTypeDesc":20},[93,68,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,73,109],"dilemm ai","arena","analyze","browser","openclaw agent","create","automation","browser automation","bot","openclaw","design","strategy","headless","compete","submit","matchmaking","use",{"skillNo":111,"name":112,"nameZh":6,"description":113,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":114,"categories":115,"keywords":119,"publishedAt":22},"01M6G8HWAF3K9SW7NP3Z83CPJ6","arxiv-paper-reviews","Interact with arXiv Crawler API to fetch papers, read reviews, and submit comments. Use when working with arXiv papers, fetching paper lists by date\u002Fcategory\u002Finterest, viewing paper details with comments, or submitting paper reviews via API at http:\u002F\u002F150.158.152.82:8000.","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fzxrys\u002Fweak-accept\u002FSKILL.md",[116],{"categoryNo":117,"categoryName":118,"taxonomyType":19,"taxonomyTypeDesc":20},"01JBSEEDCAT000000000000021","资料检索与研究",[120,121,122,123,124,125,126,69,127,107,109,128,68,129,130],"arxiv paper reviews","reviews","arxiv","paper","crawler","papers","comments","fetch","read","http","via",{"skillNo":132,"name":112,"nameZh":6,"description":113,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":133,"categories":134,"keywords":136,"publishedAt":22},"01M6G8HQJ7N7WMY6YV7D7SSJ16","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fzxrys\u002Farxiv-paper-reviews\u002FSKILL.md",[135],{"categoryNo":117,"categoryName":118,"taxonomyType":19,"taxonomyTypeDesc":20},[123,122,121,120,130,125,126,69,124,107,109,127,128,68,129],{"skillNo":138,"name":139,"nameZh":6,"description":140,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":141,"categories":142,"keywords":143,"publishedAt":22},"01M6G8HM95Y64JNVFC2HN4E2BG","git-summary","Get a quick summary of the current Git repository including status, recent commits, branches, and contributors.","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fzweack\u002Fgit-summary\u002FSKILL.md",[],[144,145,146,147,148,149,150,151,152,153,154,155,156],"git","summary","git summary","commits","repository","win32","status","linux","contributors","true","quick","get","branches",{"skillNo":158,"name":159,"nameZh":6,"description":160,"descriptionZh":6,"repositoryFullName":7,"ownerLogin":8,"ownerAvatarUrl":9,"ownerAccountNo":10,"ownerDisplayName":6,"repositoryNo":11,"starsCount":12,"licenseSpdxId":13,"licenseFileUrl":6,"sourceHtmlUrl":161,"categories":162,"keywords":167,"publishedAt":22},"01M6G8HGEGF05CNEJCGVYFSC4R","agent-constitution","Interact with AgentConstitution governance contracts on Base Sepolia. Check compliance, read rules, log actions, query governance state.","https:\u002F\u002Fgithub.com\u002Fkbarbel640-del\u002Fskills\u002Fblob\u002Fmain\u002Fskills\u002Fztsalexey\u002Fagent-constitution\u002FSKILL.md",[163,164],{"categoryNo":17,"categoryName":18,"taxonomyType":19,"taxonomyTypeDesc":20},{"categoryNo":165,"categoryName":166,"taxonomyType":63,"taxonomyTypeDesc":64},"01JBSEEDCAT000000000000037","律师与法务",[168,169,170,171,69,172,173,26,174,128,175,176,177,178,179,82,180,181,182],"agent constitution","constitution","contracts","tree","query","base","log","check","Rules","projects","compliance","actions","state","governance","github"]