[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"skill:01M6DJGCJSVF0GGJGRDH14R7BT":3,"skill-same:01M6DJGCJSVF0GGJGRDH14R7BT":78},{"skillNo":4,"name":5,"nameZh":6,"description":7,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":16,"categories":17,"keywords":18,"publishedAt":26,"linkOnly":27,"markdownContent":28,"markdownBody":29,"frontMatter":30,"refName":34,"commitSha":35,"skillDirectory":36,"forksCount":37,"repositoryHtmlUrl":38,"repositoryHomepageUrl":6,"ownerHtmlUrl":39,"ownerBlogUrl":6,"ownerDescription":40,"updatedAt":41,"install":42,"resources":55},"01M6DJGCJSVF0GGJGRDH14R7BT","variant-clinical-significance",null,"Query NCBI ClinVar for variant clinical pathogenicity classification (Pathogenic\u002FBenign\u002FVUS), review status and associated diseases.","InternScience\u002FDrClaw","InternScience","https:\u002F\u002Favatars.githubusercontent.com\u002Fu\u002F154449623?v=4","01M6DHY1ZF02QASNAVMNPT7NP6","Intern Science","01M6DHY2523FY56Q5572NKAAD0",172,"MIT","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Fagent_hub\u002Ftemplates\u002Fgenomics\u002Fskills\u002Fvariant-clinical-significance\u002FSKILL.md",[],[19,20,21,22,23,24,25],"clinical","variant clinical significance","review","benign","status","classification","query","2026-11-10 10:12:30",false,"---\nname: variant-clinical-significance\ndescription: \"Query NCBI ClinVar for variant clinical pathogenicity classification (Pathogenic\u002FBenign\u002FVUS), review status and associated diseases.\"\nlicense: MIT license\nmetadata:\n    skill-author: PJLab\n---\n\n# ClinVar Clinical Significance\n\n## Usage\n\n### Tool Description\n\n```tex\nQuery dbSNP refsnp API to extract ClinVar RCV clinical records for a variant.\nAPI: GET https:\u002F\u002Fapi.ncbi.nlm.nih.gov\u002Fvariation\u002Fv0\u002Frefsnp\u002F{rsid_number}\nArgs:\n    rs_id (str): dbSNP rsID (e.g. \"rs7412\")\nReturn:\n    ClinVar RCV records: clinical significance (Pathogenic\u002FBenign\u002FVUS\u002Fdrug-response etc.),\n    review status, associated diseases, accession numbers.\n```\n\n### Query Example\n\n```python\nimport requests\n\nrs_id = \"rs7412\"\n\n# 通过 rsID 查询 dbSNP，提取 ClinVar RCV 记录\nrsid_num = rs_id.replace(\"rs\", \"\")\nurl = f\"https:\u002F\u002Fapi.ncbi.nlm.nih.gov\u002Fvariation\u002Fv0\u002Frefsnp\u002F{rsid_num}\"\nresp = requests.get(url, timeout=30).json()\nsnapshot = resp.get(\"primary_snapshot_data\", {})\n\nfor ann in snapshot.get(\"allele_annotations\", []):\n    for clin in ann.get(\"clinical\", []):\n        accession = clin.get(\"accession_version\", \"\")\n        diseases = clin.get(\"disease_names\", [])\n        significances = clin.get(\"clinical_significances\", [])\n        review = clin.get(\"review_status\", \"\")\n        print(f\"[ClinVar RCV] {accession}: {significances}, diseases={diseases}, review={review}\")\n```\n","# ClinVar Clinical Significance\n\n## Usage\n\n### Tool Description\n\n```tex\nQuery dbSNP refsnp API to extract ClinVar RCV clinical records for a variant.\nAPI: GET https:\u002F\u002Fapi.ncbi.nlm.nih.gov\u002Fvariation\u002Fv0\u002Frefsnp\u002F{rsid_number}\nArgs:\n    rs_id (str): dbSNP rsID (e.g. \"rs7412\")\nReturn:\n    ClinVar RCV records: clinical significance (Pathogenic\u002FBenign\u002FVUS\u002Fdrug-response etc.),\n    review status, associated diseases, accession numbers.\n```\n\n### Query Example\n\n```python\nimport requests\n\nrs_id = \"rs7412\"\n\n# 通过 rsID 查询 dbSNP，提取 ClinVar RCV 记录\nrsid_num = rs_id.replace(\"rs\", \"\")\nurl = f\"https:\u002F\u002Fapi.ncbi.nlm.nih.gov\u002Fvariation\u002Fv0\u002Frefsnp\u002F{rsid_num}\"\nresp = requests.get(url, timeout=30).json()\nsnapshot = resp.get(\"primary_snapshot_data\", {})\n\nfor ann in snapshot.get(\"allele_annotations\", []):\n    for clin in ann.get(\"clinical\", []):\n        accession = clin.get(\"accession_version\", \"\")\n        diseases = clin.get(\"disease_names\", [])\n        significances = clin.get(\"clinical_significances\", [])\n        review = clin.get(\"review_status\", \"\")\n        print(f\"[ClinVar RCV] {accession}: {significances}, diseases={diseases}, review={review}\")\n```\n",{"name":5,"license":31,"metadata":32,"description":7},"MIT license",{"skill-author":33},"PJLab","main","4f96df0d9df0eae24a992afabe08edec5fc575f0","drclaw\u002Fagent_hub\u002Ftemplates\u002Fgenomics\u002Fskills\u002Fvariant-clinical-significance",10,"https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw","https:\u002F\u002Fgithub.com\u002FInternScience","Shanghai Artificial Intelligence Laboratory","2026-03-20 17:06:10",{"source":8,"skillName":5,"commands":43,"prompt":53,"zipAvailable":54},[44,47,50],{"tool":45,"command":46},"npx","npx skills add 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scientific claims and evidence quality. Use for assessing experimental design validity, identifying biases and confounders, applying evidence grading frameworks (GRADE, Cochrane Risk of Bias), or teaching critical analysis. Best for understanding evidence quality, identifying flaws. For formal peer review writing use peer-review.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fthinking\u002Fscientific-critical-thinking\u002FSKILL.md",[85,90],{"categoryNo":86,"categoryName":87,"taxonomyType":88,"taxonomyTypeDesc":89},"01JBSEEDCAT000000000000015","视觉设计","SCENARIO","使用场景",{"categoryNo":91,"categoryName":92,"taxonomyType":93,"taxonomyTypeDesc":94},"01JBSEEDCAT000000000000032","设计师","PROFESSION","适用职业",[96,97,98,99,100,21,101,102,103,104,105,106,107,108,109,110,111,112,113,114],"critical","scientific critical thinking","thinking","design","writing","risk","analysis","peer review","Bash","quality","read","write","edit","use","evidence","peer","frameworks","teaching","bias",{"skillNo":116,"name":117,"nameZh":6,"description":118,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":119,"categories":120,"keywords":121,"publishedAt":26},"01M6DMQ77Z121463E049G2DG8K","scientific-brainstorming","Creative research ideation and exploration. Use for open-ended brainstorming sessions, exploring interdisciplinary connections, challenging assumptions, or identifying research gaps. Best for early-stage research planning when you do not have specific observations yet. For formulating testable hypotheses from data use hypothesis-generation.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fthinking\u002Fscientific-brainstorming\u002FSKILL.md",[],[122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,109],"brainstorming","scientific brainstorming","research ideation","stage","connections","generation","exploration","do","planning","creative","ideation","research","sessions","data","hypothesis","open",{"skillNo":139,"name":140,"nameZh":6,"description":141,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":142,"categories":143,"keywords":150,"publishedAt":26},"01M6DMPV4AMCCTWARGPSFHDWJB","scientific-literature-search","Search scientific literature and research papers using FlowSearch to find relevant academic articles and publications.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fsearch\u002Fscientific-literature-search\u002FSKILL.md",[144,147],{"categoryNo":145,"categoryName":146,"taxonomyType":88,"taxonomyTypeDesc":89},"01JBSEEDCAT000000000000021","资料检索与研究",{"categoryNo":148,"categoryName":149,"taxonomyType":88,"taxonomyTypeDesc":89},"01JBSEEDCAT000000000000023","Skill与智能体开发",[151,152,133,153,154,155],"search","scientific literature search","find","Academic","搜索",{"skillNo":157,"name":158,"nameZh":6,"description":159,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":160,"categories":161,"keywords":168,"publishedAt":26},"01M6DMPQJP8HVFV54V05D6K9HA","pubmed-article-search","Search PubMed database for scientific articles and publications to retrieve biomedical literature.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fsearch\u002Fpubmed-article-search\u002FSKILL.md",[162,165],{"categoryNo":163,"categoryName":164,"taxonomyType":88,"taxonomyTypeDesc":89},"01JBSEEDCAT000000000000018","写作与文案",{"categoryNo":166,"categoryName":167,"taxonomyType":93,"taxonomyTypeDesc":94},"01JBSEEDCAT000000000000036","内容创作者",[169,170,151,155,171,172,173],"pubmed article search","article","database","pubmed database","biomedical",{"skillNo":175,"name":176,"nameZh":6,"description":177,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":178,"categories":179,"keywords":181,"publishedAt":26},"01M6DMPK4H3JQ185M97BRB9KQJ","biomedical-web-search","Search biomedical literature and web content using Tavily search engine for research and clinical information.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fsearch\u002Fbiomedical-web-search\u002FSKILL.md",[180],{"categoryNo":145,"categoryName":146,"taxonomyType":88,"taxonomyTypeDesc":89},[182,173,183,151,184,185,133,186,187,155,19],"biomedical web search","web search","web","tavily","content","engine",{"skillNo":189,"name":190,"nameZh":6,"description":191,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":192,"categories":193,"keywords":195,"publishedAt":26},"01M6DMNNJH9V1S5PQHZRX0N934","uniprot-protein-retrieval","Retrieve protein sequences and functional information from UniProt database by protein name, enabling protein analysis and bioinformatics workflows.","https:\u002F\u002Fgithub.com\u002FInternScience\u002FDrClaw\u002Fblob\u002Fmain\u002Fdrclaw\u002Flocal_skill_hub\u002Fscience\u002Fprotein\u002Funiprot-protein-retrieval\u002FSKILL.md",[194],{"categoryNo":148,"categoryName":149,"taxonomyType":88,"taxonomyTypeDesc":89},[196,171,102,197,198,199,200],"uniprot protein retrieval","uniprot database","bioinformatics","name","workflows"]