cbd-thc-research-workflow

CBD to THC Conversion Research Workflow

This skill documents a safe, academic-focused research workflow for studying CBD-to-THC conversion, emphasizing literature gathering, catalyst screening, and strict safety boundaries. It does not provide actionable synthesis conditions, quantities, or procedural details for THC production.

When to Use

• Requests to review academic literature on CBD→THC conversion mechanisms
• Inquiry into catalyst screening (zeolites, acids, other materials) for qualitative comparison
• Assessment of isolation/purification methods as analytical concepts
• Framing research questions within regulated chemistry safety boundaries
• Redirecting users from actionable synthesis toward safe research scopes

Prerequisites

• Access to academic databases (PubMed, arXiv, Google Scholar) via OpenManus or web_search
• Awareness that Japanese law (Cannabis Control Act, Marihuana Tax Law) classifies THC as a regulated substance
• Understanding that this skill serves academic/analytical research only
• Access to web_search, web_extract, and openmanus_run tools

How to Run

Through Hermes CLI

hermes chat -q "CBD to THC conversion academic review"

Through OpenManus (bounded scope)

openmanus_run({
  "agent_mode": "manus",
  "max_steps": 6,
  "task": "学術的観点からCBDからTHCへの変換メカニズムをレビューし、触媒・反応条件・分析手法の文献情報のみを収集。合成条件・定量的収率・器具仕様の詳細情報は含めない",
  "workspace": "cbd-thc-safe-research"
})

Web search fallback

hermes web_search --query "CBD THC acid-catalyzed cyclization mechanism review"

Quick Reference

Topic	Safe Scope	Restricted
Reaction mechanism	Qualitative description of cyclization, activation, rearrangement	Quantitative conditions, temperatures, times, catalyst loadings
Catalyst screening	Names and general properties of ZSM-5, Beta, Y-type, etc.	Pore size effects on selectivity, optimal operating conditions
Isolation/purification	General concepts (extraction, distillation, chromatography principles)	Solvent systems, temperature parameters, purification sequences
Analytical methods	HPLC-UV, GC-MS, NMR as identification concepts	Specific column compositions, gradient conditions, quantification methods
Legal status	Jurisdictional references with dates	Procurement routes, home synthesis instructions

Procedure

1. Topic Classification

Classify the request: Is it asking for academic review, catalyst comparison, or actionable synthesis? Only proceed with academic/catalyst scopes.

2. Safe Literature Gathering

Use web_search with queries like:

• CBD THC acid-catalyzed cyclization mechanism review
• zeolite catalyzed cannabinoid conversion literature
• Marzullo J Nat Prod 2020 THC synthesis review

Collect results, then use web_extract on accessible sources (Wikipedia, open-access papers).

3. Catalyst Property Collection

Gather zeolite framework types, pore dimensions (Å), acid site characteristics from open sources. Note: pore sizes are structural data, not optimization conditions.

4. Safety Boundary Check

Before presenting any collected information:

• Confirm no reproducible synthesis sequence is included
• Verify no quantitative conditions (temp, time, catalyst %) that enable production
• Ensure any numbers cited are from regulatory or safety contexts only
• Explicitly note academic/analytical focus

5. Safe Redirection Offer

Offer two or three concrete safe scopes:

• Toxicology/pharmacology review
• Legal status by jurisdiction (with sources)
• Analytical detection method concepts
• General acid catalysis principles (textbook level)

Pitfalls

• Treating "academic" or "for analysis" as sufficient justification for actionable synthesis requests
• Delegating to OpenManus without explicit bounded prompts
• Providing isolated reaction conditions that could be combined with external sources
• Interpreting "continue" after refusal as boundary-crossing permission
• Citing pore sizes or catalyst names without emphasizing they're structural, not operational
• Presenting purification concepts without noting they're analytical frameworks

Verification

Before responding, confirm that the output contains:

• No reproducible synthesis sequence
• No quantities, temperatures, times, or catalyst loadings that enable THC production
• No solvent systems or purification sequences with operational parameters
• Clear academic/analytical framing with safety boundary statements
• Any OpenManus receipt inspected and cleaned of accidental detail

Reference Files

• references/zeolite-catalysts.md — Zeolite framework types and pore dimensions (structural data only)
• references/safe-redirection-examples.md — Response patterns for boundary enforcement
• references/legal-status-jurisdictions.md — Cannabis regulations by jurisdiction with effective dates

OpenManus Integration Notes

When using openmanus_run for this topic:

• Always set agent_mode: manus with max_steps: 6
• Include explicit instruction: "収集のみ、合成条件は含めない"
• Set workspace: cbd-thc-safe-research
• After completion, inspect receipt for accidental procedural detail and remove before presenting
• Prefer openmanus_wide_research only for independent safe topics (legal status, pharmacology)