[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"skill:01M6CYF2N2K58KHD65EGJSCMCX":3,"skill-same:01M6CYF2N2K58KHD65EGJSCMCX":101},{"skillNo":4,"name":5,"nameZh":6,"description":7,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":16,"categories":17,"keywords":31,"publishedAt":51,"linkOnly":52,"markdownContent":53,"markdownBody":54,"frontMatter":55,"refName":59,"commitSha":60,"skillDirectory":61,"forksCount":62,"repositoryHtmlUrl":63,"repositoryHomepageUrl":64,"ownerHtmlUrl":65,"ownerBlogUrl":66,"ownerDescription":67,"updatedAt":68,"install":69,"resources":82},"01M6CYF2N2K58KHD65EGJSCMCX","esm",null,"Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.","eric861129\u002FSKILLS_All-in-one","eric861129","https:\u002F\u002Favatars.githubusercontent.com\u002Fu\u002F74950944?v=4","01M6CXHDYEYRPFGGV4EFXCSYCF","ChiYu-Huang","01M6CXHE2J5CN1EBTY0FKV3ZKW",52,"MIT","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002FSKILL.md",[18,23,26],{"categoryNo":19,"categoryName":20,"taxonomyType":21,"taxonomyTypeDesc":22},"01JBSEEDCAT000000000000010","后端与接口","SCENARIO","使用场景",{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},"01JBSEEDCAT000000000000023","Skill与智能体开发",{"categoryNo":27,"categoryName":28,"taxonomyType":29,"taxonomyTypeDesc":30},"01JBSEEDCAT000000000000030","开发工程师","PROFESSION","适用职业",[5,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50],"proteins","design","local","across","structure","language","models","use","model","api","forge","engineering","cloud","multimodal","embeddings","toolkit","tasks","inference","model usage","2026-11-10 10:12:30",false,"---\nname: esm\ndescription: Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.\nlicense: MIT license\nmetadata:\n    skill-author: K-Dense Inc.\n---\n\n# ESM: Evolutionary Scale Modeling\n\n## Overview\n\nESM provides state-of-the-art protein language models for understanding, generating, and designing proteins. This skill enables working with two model families: ESM3 for generative protein design across sequence, structure, and function, and ESM C for efficient protein representation learning and embeddings.\n\n## Core Capabilities\n\n### 1. Protein Sequence Generation with ESM3\n\nGenerate novel protein sequences with desired properties using multimodal generative modeling.\n\n**When to use:**\n- Designing proteins with specific functional properties\n- Completing partial protein sequences\n- Generating variants of existing proteins\n- Creating proteins with desired structural characteristics\n\n**Basic usage:**\n\n```python\nfrom esm.models.esm3 import ESM3\nfrom esm.sdk.api import ESM3InferenceClient, ESMProtein, GenerationConfig\n\n# Load model locally\nmodel: ESM3InferenceClient = ESM3.from_pretrained(\"esm3-sm-open-v1\").to(\"cuda\")\n\n# Create protein prompt\nprotein = ESMProtein(sequence=\"MPRT___KEND\")  # '_' represents masked positions\n\n# Generate completion\nprotein = model.generate(protein, GenerationConfig(track=\"sequence\", num_steps=8))\nprint(protein.sequence)\n```\n\n**For remote\u002Fcloud usage via Forge API:**\n\n```python\nfrom esm.sdk.forge import ESM3ForgeInferenceClient\nfrom esm.sdk.api import ESMProtein, GenerationConfig\n\n# Connect to Forge\nmodel = ESM3ForgeInferenceClient(model=\"esm3-medium-2024-08\", url=\"https:\u002F\u002Fforge.evolutionaryscale.ai\", token=\"\u003Ctoken>\")\n\n# Generate\nprotein = model.generate(protein, GenerationConfig(track=\"sequence\", num_steps=8))\n```\n\nSee `references\u002Fesm3-api.md` for detailed ESM3 model specifications, advanced generation configurations, and multimodal prompting examples.\n\n### 2. Structure Prediction and Inverse Folding\n\nUse ESM3's structure track for structure prediction from sequence or inverse folding (sequence design from structure).\n\n**Structure prediction:**\n\n```python\nfrom esm.sdk.api import ESM3InferenceClient, ESMProtein, GenerationConfig\n\n# Predict structure from sequence\nprotein = ESMProtein(sequence=\"MPRTKEINDAGLIVHSP...\")\nprotein_with_structure = model.generate(\n    protein,\n    GenerationConfig(track=\"structure\", num_steps=protein.sequence.count(\"_\"))\n)\n\n# Access predicted structure\ncoordinates = protein_with_structure.coordinates  # 3D coordinates\npdb_string = protein_with_structure.to_pdb()\n```\n\n**Inverse folding (sequence from structure):**\n\n```python\n# Design sequence for a target structure\nprotein_with_structure = ESMProtein.from_pdb(\"target_structure.pdb\")\nprotein_with_structure.sequence = None  # Remove sequence\n\n# Generate sequence that folds to this structure\ndesigned_protein = model.generate(\n    protein_with_structure,\n    GenerationConfig(track=\"sequence\", num_steps=50, temperature=0.7)\n)\n```\n\n### 3. Protein Embeddings with ESM C\n\nGenerate high-quality embeddings for downstream tasks like function prediction, classification, or similarity analysis.\n\n**When to use:**\n- Extracting protein representations for machine learning\n- Computing sequence similarities\n- Feature extraction for protein classification\n- Transfer learning for protein-related tasks\n\n**Basic usage:**\n\n```python\nfrom esm.models.esmc import ESMC\nfrom esm.sdk.api import ESMProtein\n\n# Load ESM C model\nmodel = ESMC.from_pretrained(\"esmc-300m\").to(\"cuda\")\n\n# Get embeddings\nprotein = ESMProtein(sequence=\"MPRTKEINDAGLIVHSP...\")\nprotein_tensor = model.encode(protein)\n\n# Generate embeddings\nembeddings = model.forward(protein_tensor)\n```\n\n**Batch processing:**\n\n```python\n# Encode multiple proteins\nproteins = [\n    ESMProtein(sequence=\"MPRTKEIND...\"),\n    ESMProtein(sequence=\"AGLIVHSPQ...\"),\n    ESMProtein(sequence=\"KTEFLNDGR...\")\n]\n\nembeddings_list = [model.logits(model.forward(model.encode(p))) for p in proteins]\n```\n\nSee `references\u002Fesm-c-api.md` for ESM C model details, efficiency comparisons, and advanced embedding strategies.\n\n### 4. Function Conditioning and Annotation\n\nUse ESM3's function track to generate proteins with specific functional annotations or predict function from sequence.\n\n**Function-conditioned generation:**\n\n```python\nfrom esm.sdk.api import ESMProtein, FunctionAnnotation, GenerationConfig\n\n# Create protein with desired function\nprotein = ESMProtein(\n    sequence=\"_\" * 200,  # Generate 200 residue protein\n    function_annotations=[\n        FunctionAnnotation(label=\"fluorescent_protein\", start=50, end=150)\n    ]\n)\n\n# Generate sequence with specified function\nfunctional_protein = model.generate(\n    protein,\n    GenerationConfig(track=\"sequence\", num_steps=200)\n)\n```\n\n### 5. Chain-of-Thought Generation\n\nIteratively refine protein designs using ESM3's chain-of-thought generation approach.\n\n```python\nfrom esm.sdk.api import GenerationConfig\n\n# Multi-step refinement\nprotein = ESMProtein(sequence=\"MPRT\" + \"_\" * 100 + \"KEND\")\n\n# Step 1: Generate initial structure\nconfig = GenerationConfig(track=\"structure\", num_steps=50)\nprotein = model.generate(protein, config)\n\n# Step 2: Refine sequence based on structure\nconfig = GenerationConfig(track=\"sequence\", num_steps=50, temperature=0.5)\nprotein = model.generate(protein, config)\n\n# Step 3: Predict function\nconfig = GenerationConfig(track=\"function\", num_steps=20)\nprotein = model.generate(protein, config)\n```\n\n### 6. Batch Processing with Forge API\n\nProcess multiple proteins efficiently using Forge's async executor.\n\n```python\nfrom esm.sdk.forge import ESM3ForgeInferenceClient\nimport asyncio\n\nclient = ESM3ForgeInferenceClient(model=\"esm3-medium-2024-08\", token=\"\u003Ctoken>\")\n\n# Async batch processing\nasync def batch_generate(proteins_list):\n    tasks = [\n        client.async_generate(protein, GenerationConfig(track=\"sequence\"))\n        for protein in proteins_list\n    ]\n    return await asyncio.gather(*tasks)\n\n# Execute\nproteins = [ESMProtein(sequence=f\"MPRT{'_' * 50}KEND\") for _ in range(10)]\nresults = asyncio.run(batch_generate(proteins))\n```\n\nSee `references\u002Fforge-api.md` for detailed Forge API documentation, authentication, rate limits, and batch processing patterns.\n\n## Model Selection Guide\n\n**ESM3 Models (Generative):**\n- `esm3-sm-open-v1` (1.4B) - Open weights, local usage, good for experimentation\n- `esm3-medium-2024-08` (7B) - Best balance of quality and speed (Forge only)\n- `esm3-large-2024-03` (98B) - Highest quality, slower (Forge only)\n\n**ESM C Models (Embeddings):**\n- `esmc-300m` (30 layers) - Lightweight, fast inference\n- `esmc-600m` (36 layers) - Balanced performance\n- `esmc-6b` (80 layers) - Maximum representation quality\n\n**Selection criteria:**\n- **Local development\u002Ftesting:** Use `esm3-sm-open-v1` or `esmc-300m`\n- **Production quality:** Use `esm3-medium-2024-08` via Forge\n- **Maximum accuracy:** Use `esm3-large-2024-03` or `esmc-6b`\n- **High throughput:** Use Forge API with batch executor\n- **Cost optimization:** Use smaller models, implement caching strategies\n\n## Installation\n\n**Basic installation:**\n\n```bash\nuv pip install esm\n```\n\n**With Flash Attention (recommended for faster inference):**\n\n```bash\nuv pip install esm\nuv pip install flash-attn --no-build-isolation\n```\n\n**For Forge API access:**\n\n```bash\nuv pip install esm  # SDK includes Forge client\n```\n\nNo additional dependencies needed. Obtain Forge API token at https:\u002F\u002Fforge.evolutionaryscale.ai\n\n## Common Workflows\n\nFor detailed examples and complete workflows, see `references\u002Fworkflows.md` which includes:\n- Novel GFP design with chain-of-thought\n- Protein variant generation and screening\n- Structure-based sequence optimization\n- Function prediction pipelines\n- Embedding-based clustering and analysis\n\n## References\n\nThis skill includes comprehensive reference documentation:\n\n- `references\u002Fesm3-api.md` - ESM3 model architecture, API reference, generation parameters, and multimodal prompting\n- `references\u002Fesm-c-api.md` - ESM C model details, embedding strategies, and performance optimization\n- `references\u002Fforge-api.md` - Forge platform documentation, authentication, batch processing, and deployment\n- `references\u002Fworkflows.md` - Complete examples and common workflow patterns\n\nThese references contain detailed API specifications, parameter descriptions, and advanced usage patterns. Load them as needed for specific tasks.\n\n## Best Practices\n\n**For generation tasks:**\n- Start with smaller models for prototyping (`esm3-sm-open-v1`)\n- Use temperature parameter to control diversity (0.0 = deterministic, 1.0 = diverse)\n- Implement iterative refinement with chain-of-thought for complex designs\n- Validate generated sequences with structure prediction or wet-lab experiments\n\n**For embedding tasks:**\n- Batch process sequences when possible for efficiency\n- Cache embeddings for repeated analyses\n- Normalize embeddings when computing similarities\n- Use appropriate model size based on downstream task requirements\n\n**For production deployment:**\n- Use Forge API for scalability and latest models\n- Implement error handling and retry logic for API calls\n- Monitor token usage and implement rate limiting\n- Consider AWS SageMaker deployment for dedicated infrastructure\n\n## Resources and Documentation\n\n- **GitHub Repository:** https:\u002F\u002Fgithub.com\u002Fevolutionaryscale\u002Fesm\n- **Forge Platform:** https:\u002F\u002Fforge.evolutionaryscale.ai\n- **Scientific Paper:** Hayes et al., Science (2025) - https:\u002F\u002Fwww.science.org\u002Fdoi\u002F10.1126\u002Fscience.ads0018\n- **Blog Posts:**\n  - ESM3 Release: https:\u002F\u002Fwww.evolutionaryscale.ai\u002Fblog\u002Fesm3-release\n  - ESM C Launch: https:\u002F\u002Fwww.evolutionaryscale.ai\u002Fblog\u002Fesm-cambrian\n- **Community:** Slack community at https:\u002F\u002Fbit.ly\u002F3FKwcWd\n- **Model Weights:** HuggingFace EvolutionaryScale organization\n\n## Responsible Use\n\nESM is designed for beneficial applications in protein engineering, drug discovery, and scientific research. Follow the Responsible Biodesign Framework (https:\u002F\u002Fresponsiblebiodesign.ai\u002F) when designing novel proteins. Consider biosafety and ethical implications of protein designs before experimental validation.\n\n","# ESM: Evolutionary Scale Modeling\n\n## Overview\n\nESM provides state-of-the-art protein language models for understanding, generating, and designing proteins. This skill enables working with two model families: ESM3 for generative protein design across sequence, structure, and function, and ESM C for efficient protein representation learning and embeddings.\n\n## Core Capabilities\n\n### 1. Protein Sequence Generation with ESM3\n\nGenerate novel protein sequences with desired properties using multimodal generative modeling.\n\n**When to use:**\n- Designing proteins with specific functional properties\n- Completing partial protein sequences\n- Generating variants of existing proteins\n- Creating proteins with desired structural characteristics\n\n**Basic usage:**\n\n```python\nfrom esm.models.esm3 import ESM3\nfrom esm.sdk.api import ESM3InferenceClient, ESMProtein, GenerationConfig\n\n# Load model locally\nmodel: ESM3InferenceClient = ESM3.from_pretrained(\"esm3-sm-open-v1\").to(\"cuda\")\n\n# Create protein prompt\nprotein = ESMProtein(sequence=\"MPRT___KEND\")  # '_' represents masked positions\n\n# Generate completion\nprotein = model.generate(protein, GenerationConfig(track=\"sequence\", num_steps=8))\nprint(protein.sequence)\n```\n\n**For remote\u002Fcloud usage via Forge API:**\n\n```python\nfrom esm.sdk.forge import ESM3ForgeInferenceClient\nfrom esm.sdk.api import ESMProtein, GenerationConfig\n\n# Connect to Forge\nmodel = ESM3ForgeInferenceClient(model=\"esm3-medium-2024-08\", url=\"https:\u002F\u002Fforge.evolutionaryscale.ai\", token=\"\u003Ctoken>\")\n\n# Generate\nprotein = model.generate(protein, GenerationConfig(track=\"sequence\", num_steps=8))\n```\n\nSee `references\u002Fesm3-api.md` for detailed ESM3 model specifications, advanced generation configurations, and multimodal prompting examples.\n\n### 2. Structure Prediction and Inverse Folding\n\nUse ESM3's structure track for structure prediction from sequence or inverse folding (sequence design from structure).\n\n**Structure prediction:**\n\n```python\nfrom esm.sdk.api import ESM3InferenceClient, ESMProtein, GenerationConfig\n\n# Predict structure from sequence\nprotein = ESMProtein(sequence=\"MPRTKEINDAGLIVHSP...\")\nprotein_with_structure = model.generate(\n    protein,\n    GenerationConfig(track=\"structure\", num_steps=protein.sequence.count(\"_\"))\n)\n\n# Access predicted structure\ncoordinates = protein_with_structure.coordinates  # 3D coordinates\npdb_string = protein_with_structure.to_pdb()\n```\n\n**Inverse folding (sequence from structure):**\n\n```python\n# Design sequence for a target structure\nprotein_with_structure = ESMProtein.from_pdb(\"target_structure.pdb\")\nprotein_with_structure.sequence = None  # Remove sequence\n\n# Generate sequence that folds to this structure\ndesigned_protein = model.generate(\n    protein_with_structure,\n    GenerationConfig(track=\"sequence\", num_steps=50, temperature=0.7)\n)\n```\n\n### 3. Protein Embeddings with ESM C\n\nGenerate high-quality embeddings for downstream tasks like function prediction, classification, or similarity analysis.\n\n**When to use:**\n- Extracting protein representations for machine learning\n- Computing sequence similarities\n- Feature extraction for protein classification\n- Transfer learning for protein-related tasks\n\n**Basic usage:**\n\n```python\nfrom esm.models.esmc import ESMC\nfrom esm.sdk.api import ESMProtein\n\n# Load ESM C model\nmodel = ESMC.from_pretrained(\"esmc-300m\").to(\"cuda\")\n\n# Get embeddings\nprotein = ESMProtein(sequence=\"MPRTKEINDAGLIVHSP...\")\nprotein_tensor = model.encode(protein)\n\n# Generate embeddings\nembeddings = model.forward(protein_tensor)\n```\n\n**Batch processing:**\n\n```python\n# Encode multiple proteins\nproteins = [\n    ESMProtein(sequence=\"MPRTKEIND...\"),\n    ESMProtein(sequence=\"AGLIVHSPQ...\"),\n    ESMProtein(sequence=\"KTEFLNDGR...\")\n]\n\nembeddings_list = [model.logits(model.forward(model.encode(p))) for p in proteins]\n```\n\nSee `references\u002Fesm-c-api.md` for ESM C model details, efficiency comparisons, and advanced embedding strategies.\n\n### 4. Function Conditioning and Annotation\n\nUse ESM3's function track to generate proteins with specific functional annotations or predict function from sequence.\n\n**Function-conditioned generation:**\n\n```python\nfrom esm.sdk.api import ESMProtein, FunctionAnnotation, GenerationConfig\n\n# Create protein with desired function\nprotein = ESMProtein(\n    sequence=\"_\" * 200,  # Generate 200 residue protein\n    function_annotations=[\n        FunctionAnnotation(label=\"fluorescent_protein\", start=50, end=150)\n    ]\n)\n\n# Generate sequence with specified function\nfunctional_protein = model.generate(\n    protein,\n    GenerationConfig(track=\"sequence\", num_steps=200)\n)\n```\n\n### 5. Chain-of-Thought Generation\n\nIteratively refine protein designs using ESM3's chain-of-thought generation approach.\n\n```python\nfrom esm.sdk.api import GenerationConfig\n\n# Multi-step refinement\nprotein = ESMProtein(sequence=\"MPRT\" + \"_\" * 100 + \"KEND\")\n\n# Step 1: Generate initial structure\nconfig = GenerationConfig(track=\"structure\", num_steps=50)\nprotein = model.generate(protein, config)\n\n# Step 2: Refine sequence based on structure\nconfig = GenerationConfig(track=\"sequence\", num_steps=50, temperature=0.5)\nprotein = model.generate(protein, config)\n\n# Step 3: Predict function\nconfig = GenerationConfig(track=\"function\", num_steps=20)\nprotein = model.generate(protein, config)\n```\n\n### 6. Batch Processing with Forge API\n\nProcess multiple proteins efficiently using Forge's async executor.\n\n```python\nfrom esm.sdk.forge import ESM3ForgeInferenceClient\nimport asyncio\n\nclient = ESM3ForgeInferenceClient(model=\"esm3-medium-2024-08\", token=\"\u003Ctoken>\")\n\n# Async batch processing\nasync def batch_generate(proteins_list):\n    tasks = [\n        client.async_generate(protein, GenerationConfig(track=\"sequence\"))\n        for protein in proteins_list\n    ]\n    return await asyncio.gather(*tasks)\n\n# Execute\nproteins = [ESMProtein(sequence=f\"MPRT{'_' * 50}KEND\") for _ in range(10)]\nresults = asyncio.run(batch_generate(proteins))\n```\n\nSee `references\u002Fforge-api.md` for detailed Forge API documentation, authentication, rate limits, and batch processing patterns.\n\n## Model Selection Guide\n\n**ESM3 Models (Generative):**\n- `esm3-sm-open-v1` (1.4B) - Open weights, local usage, good for experimentation\n- `esm3-medium-2024-08` (7B) - Best balance of quality and speed (Forge only)\n- `esm3-large-2024-03` (98B) - Highest quality, slower (Forge only)\n\n**ESM C Models (Embeddings):**\n- `esmc-300m` (30 layers) - Lightweight, fast inference\n- `esmc-600m` (36 layers) - Balanced performance\n- `esmc-6b` (80 layers) - Maximum representation quality\n\n**Selection criteria:**\n- **Local development\u002Ftesting:** Use `esm3-sm-open-v1` or `esmc-300m`\n- **Production quality:** Use `esm3-medium-2024-08` via Forge\n- **Maximum accuracy:** Use `esm3-large-2024-03` or `esmc-6b`\n- **High throughput:** Use Forge API with batch executor\n- **Cost optimization:** Use smaller models, implement caching strategies\n\n## Installation\n\n**Basic installation:**\n\n```bash\nuv pip install esm\n```\n\n**With Flash Attention (recommended for faster inference):**\n\n```bash\nuv pip install esm\nuv pip install flash-attn --no-build-isolation\n```\n\n**For Forge API access:**\n\n```bash\nuv pip install esm  # SDK includes Forge client\n```\n\nNo additional dependencies needed. Obtain Forge API token at https:\u002F\u002Fforge.evolutionaryscale.ai\n\n## Common Workflows\n\nFor detailed examples and complete workflows, see `references\u002Fworkflows.md` which includes:\n- Novel GFP design with chain-of-thought\n- Protein variant generation and screening\n- Structure-based sequence optimization\n- Function prediction pipelines\n- Embedding-based clustering and analysis\n\n## References\n\nThis skill includes comprehensive reference documentation:\n\n- `references\u002Fesm3-api.md` - ESM3 model architecture, API reference, generation parameters, and multimodal prompting\n- `references\u002Fesm-c-api.md` - ESM C model details, embedding strategies, and performance optimization\n- `references\u002Fforge-api.md` - Forge platform documentation, authentication, batch processing, and deployment\n- `references\u002Fworkflows.md` - Complete examples and common workflow patterns\n\nThese references contain detailed API specifications, parameter descriptions, and advanced usage patterns. Load them as needed for specific tasks.\n\n## Best Practices\n\n**For generation tasks:**\n- Start with smaller models for prototyping (`esm3-sm-open-v1`)\n- Use temperature parameter to control diversity (0.0 = deterministic, 1.0 = diverse)\n- Implement iterative refinement with chain-of-thought for complex designs\n- Validate generated sequences with structure prediction or wet-lab experiments\n\n**For embedding tasks:**\n- Batch process sequences when possible for efficiency\n- Cache embeddings for repeated analyses\n- Normalize embeddings when computing similarities\n- Use appropriate model size based on downstream task requirements\n\n**For production deployment:**\n- Use Forge API for scalability and latest models\n- Implement error handling and retry logic for API calls\n- Monitor token usage and implement rate limiting\n- Consider AWS SageMaker deployment for dedicated infrastructure\n\n## Resources and Documentation\n\n- **GitHub Repository:** https:\u002F\u002Fgithub.com\u002Fevolutionaryscale\u002Fesm\n- **Forge Platform:** https:\u002F\u002Fforge.evolutionaryscale.ai\n- **Scientific Paper:** Hayes et al., Science (2025) - https:\u002F\u002Fwww.science.org\u002Fdoi\u002F10.1126\u002Fscience.ads0018\n- **Blog Posts:**\n  - ESM3 Release: https:\u002F\u002Fwww.evolutionaryscale.ai\u002Fblog\u002Fesm3-release\n  - ESM C Launch: https:\u002F\u002Fwww.evolutionaryscale.ai\u002Fblog\u002Fesm-cambrian\n- **Community:** Slack community at https:\u002F\u002Fbit.ly\u002F3FKwcWd\n- **Model Weights:** HuggingFace EvolutionaryScale organization\n\n## Responsible Use\n\nESM is designed for beneficial applications in protein engineering, drug discovery, and scientific research. Follow the Responsible Biodesign Framework (https:\u002F\u002Fresponsiblebiodesign.ai\u002F) when designing novel proteins. Consider biosafety and ethical implications of protein designs before experimental validation.\n\n",{"name":5,"license":56,"metadata":57,"description":7},"MIT license",{"skill-author":58},"K-Dense Inc.","main","cbdd44aae21131521c09e42762e36178c790eacf","public\u002FSKILLS\u002FScientific & Research Tools\u002Fesm",13,"https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one","http:\u002F\u002Fhuangchiyu.com\u002FSKILLS_All-in-one\u002F","https:\u002F\u002Fgithub.com\u002Feric861129","https:\u002F\u002Fhuangchiyu.com\u002FChiYu-Blog\u002F","開發工程師，專注於 C#／.NET 系統現代化、AI-assisted engineering、開源工具與技術寫作。","2026-04-16 14:28:14",{"source":8,"skillName":5,"commands":70,"prompt":80,"zipAvailable":81},[71,74,77],{"tool":72,"command":73},"npx","npx skills add eric861129\u002FSKILLS_All-in-one --skill esm",{"tool":75,"command":76},"bunx","bunx skills add eric861129\u002FSKILLS_All-in-one --skill esm",{"tool":78,"command":79},"pnpm","pnpm dlx skills add eric861129\u002FSKILLS_All-in-one --skill esm","安装技能，技能地址：https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002FSKILL.md",true,[83,89,93,97],{"path":84,"resourceType":85,"resourceTypeDesc":86,"sizeBytes":87,"sourceHtmlUrl":88},"references\u002Fesm-c-api.md","REFERENCE","参考文档",15715,"https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002Freferences\u002Fesm-c-api.md",{"path":90,"resourceType":85,"resourceTypeDesc":86,"sizeBytes":91,"sourceHtmlUrl":92},"references\u002Fesm3-api.md",11852,"https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002Freferences\u002Fesm3-api.md",{"path":94,"resourceType":85,"resourceTypeDesc":86,"sizeBytes":95,"sourceHtmlUrl":96},"references\u002Fforge-api.md",17615,"https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002Freferences\u002Fforge-api.md",{"path":98,"resourceType":85,"resourceTypeDesc":86,"sizeBytes":99,"sourceHtmlUrl":100},"references\u002Fworkflows.md",20667,"https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FScientific & Research Tools\u002Fesm\u002Freferences\u002Fworkflows.md",[102,130,161,186,209,229],{"skillNo":103,"name":104,"nameZh":6,"description":105,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":106,"categories":107,"keywords":109,"publishedAt":51},"01M6CZ1WR3KNVTKSWH4GNWT646","what-if-oracle","Run structured What-If scenario analysis with multi-branch possibility exploration. Use this skill when the user asks speculative questions like \"what if...\", \"what would happen if...\", \"what are the possibilities\", \"explore scenarios\", \"scenario analysis\", \"possibility space\", \"what could go wrong\", \"best case \u002F worst case\", \"risk analysis\", \"contingency planning\", \"strategic options\", or any question about uncertain futures. Also trigger when the user faces a fork-in-the-road decision, wants to stress-test an idea, or needs to think through consequences before committing.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fwhat-if-oracle\u002FSKILL.md",[108],{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},[110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129],"oracle","what if oracle","go","run","planning","ux","futures","risk","analysis","explore","decision","branch","question","read","write","idea","exploration","options","stress-test","strategies",{"skillNo":131,"name":132,"nameZh":6,"description":133,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":134,"categories":135,"keywords":146,"publishedAt":51},"01M6CZ1QHGJE91A95MSN5EK5Q9","venue-templates","Access comprehensive LaTeX templates, formatting requirements, and submission guidelines for major scientific publication venues (Nature, Science, PLOS, IEEE, ACM), academic conferences (NeurIPS, ICML, CVPR, CHI), research posters, and grant proposals (NSF, NIH, DOE, DARPA). This skill should be used when preparing manuscripts for journal submission, conference papers, research posters, or grant proposals and need venue-specific formatting requirements and templates.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fvenue-templates\u002FSKILL.md",[136,139,142,143],{"categoryNo":137,"categoryName":138,"taxonomyType":21,"taxonomyTypeDesc":22},"01JBSEEDCAT000000000000018","写作与文案",{"categoryNo":140,"categoryName":141,"taxonomyType":21,"taxonomyTypeDesc":22},"01JBSEEDCAT000000000000021","资料检索与研究",{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":144,"categoryName":145,"taxonomyType":29,"taxonomyTypeDesc":30},"01JBSEEDCAT000000000000036","内容创作者",[147,148,149,150,151,152,153,154,155,156,123,124,157,158,159,160],"templates","venue templates","research","guidelines","NeurIPS","ICML","LaTeX","science","Bash","access","edit","proposals","Academic","requirements",{"skillNo":162,"name":163,"nameZh":6,"description":164,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":165,"categories":166,"keywords":169,"publishedAt":51},"01M6CZ1KBQD2E5RTFB3BGVX7CD","the-fool","Use when challenging ideas, plans, decisions, or proposals using structured critical reasoning. Invoke to play devil's advocate, run a pre-mortem, red team, or audit evidence and assumptions.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fthe-fool\u002FSKILL.md",[167,168],{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":27,"categoryName":28,"taxonomyType":29,"taxonomyTypeDesc":30},[170,171,112,172,173,113,174,175,42,176,177,178,179,180,158,181,182,183,184,185],"the fool","review","workflow","architecture","code","audit","devil","team","designer","reviewer","challenge","stress test","evidence","expert","poke","ideas",{"skillNo":187,"name":188,"nameZh":6,"description":189,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":190,"categories":191,"keywords":195,"publishedAt":51},"01M6CZ1ES826S7P1X3333E40TA","scientific-writing","Core skill for the deep research and writing tool. Write scientific manuscripts in full paragraphs (never bullet points). Use two-stage process with (1) section outlines with key points using research-lookup then (2) convert to flowing prose. IMRAD structure, citations (APA\u002FAMA\u002FVancouver), figures\u002Ftables, reporting guidelines (CONSORT\u002FSTROBE\u002FPRISMA), for research papers and journal submissions.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fscientific-writing\u002FSKILL.md",[192,193,194],{"categoryNo":137,"categoryName":138,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":144,"categoryName":145,"taxonomyType":29,"taxonomyTypeDesc":30},[196,197,150,198,199,200,201,202,155,203,123,124,157,39,204,36,205,206,207,208],"writing","scientific writing","core","reporting","deep research","Citations","Outlines","tool","never","deep","full","stage","prisma",{"skillNo":210,"name":211,"nameZh":6,"description":212,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":213,"categories":214,"keywords":216,"publishedAt":51},"01M6CZ1B2JGJTB9FRD0TW4RXXE","scientific-brainstorming","Creative research ideation and exploration. Use for open-ended brainstorming sessions, exploring interdisciplinary connections, challenging assumptions, or identifying research gaps. Best for early-stage research planning when you do not have specific observations yet. For formulating testable hypotheses from data use hypothesis-generation.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fscientific-brainstorming\u002FSKILL.md",[215],{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},[217,218,149,219,114,220,221,222,39,223,224,225,126,226,227,207,228],"brainstorming","scientific brainstorming","sessions","data","hypothesis","open","ideation","creative","do","connections","research ideation","generation",{"skillNo":230,"name":231,"nameZh":6,"description":232,"descriptionZh":6,"repositoryFullName":8,"ownerLogin":9,"ownerAvatarUrl":10,"ownerAccountNo":11,"ownerDisplayName":12,"repositoryNo":13,"starsCount":14,"licenseSpdxId":15,"licenseFileUrl":6,"sourceHtmlUrl":233,"categories":234,"keywords":239,"publishedAt":51},"01M6CZ16JG8N7A2ZX04BGE8J2Y","research-lookup","Look up current research information using the Parallel Chat API (primary) or Perplexity sonar-pro-search (academic paper searches). Automatically routes queries to the best backend. Use for finding papers, gathering research data, and verifying scientific information.","https:\u002F\u002Fgithub.com\u002Feric861129\u002FSKILLS_All-in-one\u002Fblob\u002Fmain\u002Fpublic\u002FSKILLS\u002FWriting & Research\u002Fresearch-lookup\u002FSKILL.md",[235,236,237,238],{"categoryNo":19,"categoryName":20,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":140,"categoryName":141,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":24,"categoryName":25,"taxonomyType":21,"taxonomyTypeDesc":22},{"categoryNo":27,"categoryName":28,"taxonomyType":29,"taxonomyTypeDesc":30},[149,240,241,242,220,243,41,155,244,245,123,124,157,39,246,247,248,249,250,159],"lookup","research lookup","search","perplexity","parallel","openrouter","backend","up","look","queries","chat"]